UniProt Protein Function: | IL1RL1: receptor for IL33. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of ERK1 and/or ERK2, p38-alpha, and JNK1. Apparently promotes the activation and differentiation of T-helper 2 cells. Belongs to the interleukin-1 receptor family. Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Three isoforms of the human protein are produced by alternative splicing. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 2q12 Cellular Component: extracellular matrix; integral to membrane; extracellular region; external side of plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor signaling protein activity; interleukin-1 receptor activity Biological Process: negative regulation of T-helper 1 type immune response; negative regulation of interferon-gamma production; immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation |
NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q01638 |
NCBI GenInfo Identifier: | 116242527 |
NCBI Gene ID: | 9173 |
NCBI Accession: | Q01638.4 |
UniProt Secondary Accession: | Q01638,Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44, A8K6B3, B4E0I3 |
UniProt Related Accession: | Q01638 |
Molecular Weight: | 23,723 Da |
NCBI Full Name: | Interleukin-1 receptor-like 1 |
NCBI Synonym Full Names: | interleukin 1 receptor-like 1 |
NCBI Official Symbol: | IL1RL1 |
NCBI Official Synonym Symbols: | T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R |
NCBI Protein Information: | interleukin-1 receptor-like 1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed |
UniProt Protein Name: | Interleukin-1 receptor-like 1 |
UniProt Synonym Protein Names: | Protein ST2 |
Protein Family: | Interleukin-1 receptor |
UniProt Gene Name: | IL1RL1 |
UniProt Entry Name: | ILRL1_HUMAN |