UniProt Protein Function: | IL-1RB: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q12 Cellular Component: plasma membrane Molecular Function:interleukin-1 receptor activity; protein binding Biological Process: immune response |
NCBI Summary: | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
UniProt Code: | P27930 |
NCBI GenInfo Identifier: | 124310 |
NCBI Gene ID: | 7850 |
NCBI Accession: | P27930.1 |
UniProt Secondary Accession: | P27930,Q6LCE6, Q9UE68, D3DVJ5, |
UniProt Related Accession: | P27930 |
Molecular Weight: | 33,622 Da |
NCBI Full Name: | Interleukin-1 receptor type 2 |
NCBI Synonym Full Names: | interleukin 1 receptor type 2 |
NCBI Official Symbol: | IL1R2 |
NCBI Official Synonym Symbols: | IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2 |
NCBI Protein Information: | interleukin-1 receptor type 2 |
UniProt Protein Name: | Interleukin-1 receptor type 2 |
UniProt Synonym Protein Names: | CD121 antigen-like family member B; CDw121b; IL-1 type II receptor; Interleukin-1 receptor beta; IL-1R-beta |
Protein Family: | Interleukin-1 receptor |
UniProt Gene Name: | IL1R2 |
UniProt Entry Name: | IL1R2_HUMAN |