UniProt Protein Function: | IL18BP: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular space; extracellular region Molecular Function:receptor antagonist activity; interleukin-18 binding Biological Process: T-helper 1 type immune response; response to lipopolysaccharide |
NCBI Summary: | The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] |
UniProt Code: | O95998 |
NCBI GenInfo Identifier: | 251757286 |
NCBI Gene ID: | 10068 |
NCBI Accession: | O95998.2 |
UniProt Secondary Accession: | O95998,O95993, O96027, Q9NZA9, Q9UBR7, B3KUZ0, B7WPK4 |
UniProt Related Accession: | O95998 |
Molecular Weight: | 17,478 Da |
NCBI Full Name: | Interleukin-18-binding protein |
NCBI Synonym Full Names: | interleukin 18 binding protein |
NCBI Official Symbol: | IL18BP |
NCBI Official Synonym Symbols: | IL18BPa |
NCBI Protein Information: | interleukin-18-binding protein; IL-18BP; MC51L-53L-54L homolog gene product; tadekinig-alfa |
UniProt Protein Name: | Interleukin-18-binding protein |
UniProt Synonym Protein Names: | Tadekinig-alfa |
Protein Family: | Interleukin-18-binding protein |
UniProt Gene Name: | IL18BP |
UniProt Entry Name: | I18BP_HUMAN |