IFIT2 Antibody (PACO51630)
- SKU:
- PACO51630
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IFIT2 Antibody (PACO51630) |
抗体コード: | PACO51630 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Interferon-induced protein with tetratricopeptide repeats 2 protein (130-265AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HEK293 whole cell lysate, Rat liver tissue. All lanes: IFIT2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55 kDa. Observed band size: 55 kDa.. |
![]() | IHC image of PACO51630 diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO51630 diluted at 1:600 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. |
シノニム: | Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54), IFIT2, CIG-42 G10P2 IFI54 ISG54 |
UniProt Protein Function: | IFIT2: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Can promote apoptosis. Belongs to the IFIT family. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 10q23.31 Cellular Component: endoplasmic reticulum; cytoplasm; cytosol Molecular Function:protein binding Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of protein binding; defense response to virus |
UniProt Code: | P09913 |
NCBI GenInfo Identifier: | 153082755 |
NCBI Gene ID: | 3433 |
NCBI Accession: | NP_001538.4 |
UniProt Secondary Accession: | P09913,Q5T767, |
UniProt Related Accession: | P09913 |
Molecular Weight: | 54,632 Da |
NCBI Full Name: | interferon-induced protein with tetratricopeptide repeats 2 |
NCBI Synonym Full Names: | interferon-induced protein with tetratricopeptide repeats 2 |
NCBI Official Symbol: | IFIT2 |
NCBI Official Synonym Symbols: | P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K |
NCBI Protein Information: | interferon-induced protein with tetratricopeptide repeats 2; interferon-induced protein 54; interferon-induced 54 kDa protein; Interferon, alpha-inducible protein (MW 54kD) |
UniProt Protein Name: | Interferon-induced protein with tetratricopeptide repeats 2 |
UniProt Synonym Protein Names: | ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54 |
Protein Family: | Interferon-induced protein with tetratricopeptide repeats |
UniProt Gene Name: | IFIT2 |
UniProt Entry Name: | IFIT2_HUMAN |
Antibodies |
Anti-IFIT2 Antibody (CAB13760) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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