ID3 Antibody (PACO53350)
- SKU:
- PACO53350
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ID3 Antibody (PACO53350) |
抗体コード: | PACO53350 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human DNA-binding protein inhibitor ID-3 protein (27-99AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescent analysis of Hela cells using PACO53350 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. |
シノニム: | DNA-binding protein inhibitor ID-3 (Class B basic helix-loop-helix protein 25) (bHLHb25) (Helix-loop-helix protein HEIR-1) (ID-like protein inhibitor HLH 1R21) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3), ID3, 1R21 BHLHB25 HEIR1 |
UniProt Protein Function: | ID3: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. Induced by phorbol 12-myristate 13-acetate (PMA). Interacts with COPS5 and COPS7A. Homodimer, and heterodimer with other HLH proteins. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding Chromosomal Location of Human Ortholog: 1p36.13-p36.12 Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus Molecular Function:protein binding; transcription corepressor activity Biological Process: multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q02535 |
NCBI GenInfo Identifier: | 322510035 |
NCBI Gene ID: | 3399 |
NCBI Accession: | Q02535.2 |
UniProt Secondary Accession: | Q02535,O75641, A8K1T8, |
UniProt Related Accession: | Q02535 |
Molecular Weight: | 12,999 Da |
NCBI Full Name: | DNA-binding protein inhibitor ID-3 |
NCBI Synonym Full Names: | inhibitor of DNA binding 3, HLH protein |
NCBI Official Symbol: | ID3 |
NCBI Official Synonym Symbols: | HEIR-1; bHLHb25 |
NCBI Protein Information: | DNA-binding protein inhibitor ID-3 |
UniProt Protein Name: | DNA-binding protein inhibitor ID-3 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 25; bHLHb25; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3; Inhibitor of differentiation 3 |
Protein Family: | DNA-binding protein inhibitor |
UniProt Gene Name: | ID3 |
UniProt Entry Name: | ID3_HUMAN |
Antibodies |
Anti-ID3 Antibody (CAB5375) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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