ICK Antibody (PACO51186)
- SKU:
- PACO51186
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ICK Antibody (PACO51186) |
抗体コード: | PACO51186 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein kinase ICK protein (150-275AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: PC-3 whole cell lysate. All lanes: ICK antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 72, 35 kDa. Observed band size: 72 kDa.. |
![]() | Immunohistochemistry analysis of human pancreatic cancer using PACO51186 at dilution of 1:100. |
バックグラウンド: | Required for ciliogenesis. Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). |
シノニム: | Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK), ICK, KIAA0936 |
UniProt Protein Function: | Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A. Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity. |
NCBI Summary: | Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UPZ9 |
NCBI GenInfo Identifier: | 7662388 |
NCBI Gene ID: | 22858 |
NCBI Accession: | NP_055735.1 |
UniProt Secondary Accession: | Q9UPZ9,O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, A7MD41 |
UniProt Related Accession: | Q9UPZ9 |
Molecular Weight: | 71 kDa |
NCBI Full Name: | serine/threonine-protein kinase ICK |
NCBI Synonym Full Names: | intestinal cell kinase |
NCBI Official Symbol: | ICK |
NCBI Official Synonym Symbols: | ECO; MRK; LCK2 |
NCBI Protein Information: | serine/threonine-protein kinase ICK |
UniProt Protein Name: | Serine/threonine-protein kinase ICK |
UniProt Synonym Protein Names: | Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | ICK |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |