HYAL1 Antibody (PACO43225)
- SKU:
- PACO43225
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | HYAL1 Antibody (PACO43225) |
抗体コード: | PACO43225 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Hyaluronidase-1 protein (136-435AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human endommetrial cancer using PACO43225 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO43225 at dilution of 1:100. |
バックグラウンド: | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. |
シノニム: | Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Lung carcinoma protein 1) (LuCa-1), HYAL1, LUCA1 |
UniProt Protein Function: | HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Secreted, signal peptide; Secreted; Hydrolase Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: extracellular space; lysosomal lumen; lysosome; cytoplasm; cytoplasmic vesicle Molecular Function:viral receptor activity; hyaluronan synthase activity; transcription factor binding; hyalurononglucosaminidase activity Biological Process: positive regulation of cell adhesion; glycosaminoglycan metabolic process; response to virus; pathogenesis; positive regulation of cell growth; hyaluronan catabolic process; response to antibiotic; chondroitin sulfate metabolic process; positive regulation of angiogenesis; response to reactive oxygen species; hyaluronan biosynthetic process; cartilage development; carbohydrate metabolic process; chondroitin sulfate catabolic process; negative regulation of cell growth; inflammatory response; hyaluronan metabolic process; positive regulation of growth; positive regulation of epithelial cell proliferation Disease: Mucopolysaccharidosis, Type Ix |
NCBI Summary: | This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12794 |
NCBI GenInfo Identifier: | 74735617 |
NCBI Gene ID: | 3373 |
NCBI Accession: | Q12794.2 |
UniProt Related Accession: | Q12794 |
Molecular Weight: | |
NCBI Full Name: | Hyaluronidase-1 |
NCBI Synonym Full Names: | hyaluronidase 1 |
NCBI Official Symbol: | HYAL1 |
NCBI Official Synonym Symbols: | MPS9; NAT6; LUCA1; HYAL-1 |
NCBI Protein Information: | hyaluronidase-1 |
UniProt Protein Name: | Hyaluronidase-1 |
UniProt Synonym Protein Names: | Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1 |
UniProt Gene Name: | HYAL1 |
UniProt Entry Name: | HYAL1_HUMAN |
Antibodies | ELISA Kits |
Anti-HYAL1 Antibody (CAB6623) | Human HYAL1 / Hyaluronidase-1 ELISA Kit |
Human Hyaluronidase-1 (HYAL1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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