UniProt Protein Function: | HSD3B2: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified. |
UniProt Protein Details: | Protein type:Lipid Metabolism - androgen and estrogen; EC 1.1.1.145; Endoplasmic reticulum; Isomerase; Membrane protein, integral; Oxidoreductase; EC 5.3.3.1; Mitochondrial; Lipid Metabolism - C21-steroid hormone Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; mitochondrial membrane; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space; smooth endoplasmic reticulum membrane Molecular Function:steroid delta-isomerase activity; 3-beta-hydroxy-delta5-steroid dehydrogenase activity Biological Process: steroid metabolic process; mineralocorticoid biosynthetic process; androgen biosynthetic process; glucocorticoid biosynthetic process; steroid biosynthetic process Disease: 3-beta-hydroxysteroid Dehydrogenase, Type Ii, Deficiency Of |
NCBI Summary: | The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | P26439 |
NCBI GenInfo Identifier: | 112770 |
NCBI Gene ID: | 3284 |
NCBI Accession: | P26439.2 |
UniProt Secondary Accession: | P26439,Q16010, Q53GD4, Q6AI10, Q6LDB9, Q99890, Q9UD08 A2RRA5, |
UniProt Related Accession: | P26439 |
Molecular Weight: | |
NCBI Full Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5--> |
NCBI Synonym Full Names: | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
NCBI Official Symbol: | HSD3B2 |
NCBI Official Synonym Symbols: | HSDB; HSD3B; SDR11E2 |
NCBI Protein Information: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD II; 3 beta-HSD type II; progesterone reductase; delta 5-delta 4-isomerase type II; 3-beta-HSD adrenal and gonadal type; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; short chain dehydrogenase/reductase family 11E, member 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II |
UniProt Protein Name: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 |
UniProt Synonym Protein Names: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-HSD adrenal and gonadal typeIncluding the following 2 domains:3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145)Alternative name(s):3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase |
Protein Family: | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase |
UniProt Gene Name: | HSD3B2 |
UniProt Entry Name: | 3BHS2_HUMAN |