HSD17B8 Antibody (PACO09812)
- SKU:
- PACO09812
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | HSD17B8 Antibody (PACO09812) |
抗体コード: | PACO09812 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human HSD17B8 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | hydroxysteroid (17-beta) dehydrogenase 8;HSD17B8;D6S2245E;FABG;FABGL;H2-KE6;HKE6;KE6;RING2;SDR30C1;dJ1033B10.9 ; |
UniProt Protein Function: | HSD17B8: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
UniProt Protein Details: | Protein type:Lipid Metabolism - androgen and estrogen; EC 1.1.1.239; Mitochondrial; EC 1.1.1.62; Oxidoreductase Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: mitochondrial matrix Molecular Function:3-hydroxyacyl-CoA dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; protein binding Biological Process: estrogen biosynthetic process |
NCBI Summary: | In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92506 |
NCBI GenInfo Identifier: | 12643402 |
NCBI Gene ID: | 7923 |
NCBI Accession: | Q92506.2 |
UniProt Secondary Accession: | Q92506,Q5STP7, Q9UIQ1, A6NLX7, |
UniProt Related Accession: | Q92506 |
Molecular Weight: | 26,974 Da |
NCBI Full Name: | Estradiol 17-beta-dehydrogenase 8 |
NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 8 |
NCBI Official Symbol: | HSD17B8 |
NCBI Official Synonym Symbols: | KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9 |
NCBI Protein Information: | estradiol 17-beta-dehydrogenase 8 |
UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 8 |
UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD 8; 3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.-); Protein Ke6; Ke-6; Really interesting new gene 2 protein; Short chain dehydrogenase/reductase family 30C member 1; Testosterone 17-beta-dehydrogenase 8 (EC:1.1.1.239) |
Protein Family: | Estradiol 17 beta-dehydrogenase |
UniProt Gene Name: | HSD17B8 |
UniProt Entry Name: | DHB8_HUMAN |