HS2ST1 Antibody (PACO27449)
- SKU:
- PACO27449
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | HS2ST1 Antibody (PACO27449) |
抗体コード: | PACO27449 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Heparan sulfate 2-O-sulfotransferase 1 protein (29-229AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot Positive WB detected in: Rat spleen tissue All lanes: HS2ST1 antibody at 2.7µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 42, 35, 27 kDa Observed band size: 42 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human lung cancer using PACO27449 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO27449 at dilution of 1:100. |
バックグラウンド: | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid, residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). |
シノニム: | Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-), HS2ST1, HS2ST KIAA0448 |
UniProt Protein Function: | HS2ST1: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. Belongs to the sulfotransferase 3 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.8.2.-; Transferase Chromosomal Location of Human Ortholog: 1p22.3 Cellular Component: Golgi membrane; membrane Molecular Function:heparan sulfate 2-O-sulfotransferase activity Biological Process: glycosaminoglycan biosynthetic process |
NCBI Summary: | Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008] |
UniProt Code: | Q7LGA3 |
NCBI GenInfo Identifier: | 68052326 |
NCBI Gene ID: | 9653 |
NCBI Accession: | Q7LGA3.1 |
UniProt Secondary Accession: | Q7LGA3,O75036, Q32NB5, Q8TAC5, Q9H441, Q9NUJ9, D3DT22 |
UniProt Related Accession: | Q7LGA3 |
Molecular Weight: | 26,757 Da |
NCBI Full Name: | Heparan sulfate 2-O-sulfotransferase 1 |
NCBI Synonym Full Names: | heparan sulfate 2-O-sulfotransferase 1 |
NCBI Official Symbol: | HS2ST1 |
NCBI Official Synonym Symbols: | dJ604K5.2 |
NCBI Protein Information: | heparan sulfate 2-O-sulfotransferase 1 |
UniProt Protein Name: | Heparan sulfate 2-O-sulfotransferase 1 |
Protein Family: | Heparan sulfate 2-O-sulfotransferase |
UniProt Gene Name: | HS2ST1 |
UniProt Entry Name: | HS2ST_HUMAN |