HOXD13 Antibody (PACO61302)
- SKU:
- PACO61302
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | HOXD13 Antibody (PACO61302) |
抗体コード: | PACO61302 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human Homeobox protein Hox-D13 protein (151-254AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO61302 diluted at 1:400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO61302 diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). |
シノニム: | Homeobox protein Hox-D13, Homeobox protein Hox-4I, HOXD13, HOX4I |
UniProt Protein Function: | HOXD13: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXD13 are the cause of synpolydactyly 1 (SPD1); also known as syndactyly type 2 (SDTY2). SPD1 is a limb malformation that shows a characteristic manifestation in both hands and feet. This condition is inherited as an autosomal dominant trait with reduced penetrance. Defects in HOXD13 are the cause of brachydactyly type D (BDD). BDD is characterized by short and broad terminal phalanges of the thumbs and big toes. Inheritance is autosomal dominant. Defects in HOXD13 are the cause of syndactyly type 5 (SDTY5); also known as syndactyly with metacarpal and metatarsal fusion. The metacarpals and metatarsals most commonly fused are the 4th and 5th or the 3rd and 4th. Soft tissue syndactyly usually affects the 3rd and 4th fingers and the 2nd and 3rd toes. Inheritance is autosomal dominant. Defects in HOXD13 are the cause of brachydactyly- syndactyly syndrome (BDSD). Most of affected individuals exhibit generalized shortening of the hands and feet, broad and short distal phalanges of the thumbs, and cutaneous syndactyly of toes 2 and 3. The limb phenotypes observed in this syndrome overlap those of brachydactyly types A4, D, E and syndactyly type 1. Defects in HOXD13 are the cause of brachydactyly type E (BDE1). BDE is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Inheritance is autosomal dominant. Defects in HOXD13 are a cause of VACTERL association (VACTERL); which includes also VATER association. VACTERL is an acronym for vertebral anomalies, anal atresia, congenital cardiac disease, tracheoesophageal fistula, renal anomalies, radial dysplasia, and other limb defects. Belongs to the Abd-B homeobox family. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: nucleus Molecular Function:DNA binding Biological Process: multicellular organismal development; regulation of transcription, DNA-dependent Disease: Brachydactyly, Type D; Brachydactyly, Type E1; Brachydactyly-syndactyly Syndrome; Syndactyly, Type V; Synpolydactyly 1; Vater Association |
NCBI Summary: | This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008] |
UniProt Code: | P35453 |
NCBI GenInfo Identifier: | 223590221 |
NCBI Gene ID: | 3239 |
NCBI Accession: | P35453.3 |
UniProt Related Accession: | P35453 |
Molecular Weight: | 36,101 Da |
NCBI Full Name: | Homeobox protein Hox-D13 |
NCBI Synonym Full Names: | homeobox D13 |
NCBI Official Symbol: | HOXD13 |
NCBI Official Synonym Symbols: | BDE; SPD; BDSD; SPD1; HOX4I |
NCBI Protein Information: | homeobox protein Hox-D13 |
UniProt Protein Name: | Homeobox protein Hox-D13 |
UniProt Synonym Protein Names: | Homeobox protein Hox-4I |
Protein Family: | Homeobox protein |
UniProt Gene Name: | HOXD13 |
UniProt Entry Name: | HXD13_HUMAN |