HEXIM2 Antibody, HRP conjugated (PACO27354)
- SKU:
- PACO27354
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | HEXIM2 Antibody, HRP conjugated (PACO27354) |
抗体コード: | PACO27354 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Protein HEXIM2 protein (1-286AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. |
シノニム: | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2), HEXIM2 |
UniProt Protein Function: | HEXIM2: a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Component of the 7SK snRNP complex containing at least the P-TEFb complex (CDK9/CCNT1, HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs). Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). A coiled-coil domain mediates oligomerization. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:cyclin-dependent protein kinase inhibitor activity; protein binding; snRNA binding Biological Process: negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
UniProt Code: | Q96MH2 |
NCBI GenInfo Identifier: | 74732374 |
NCBI Gene ID: | 124790 |
NCBI Accession: | Q96MH2.1 |
UniProt Secondary Accession: | Q96MH2,D3DX66, |
UniProt Related Accession: | Q96MH2 |
Molecular Weight: | 32,419 Da |
NCBI Full Name: | Protein HEXIM2 |
NCBI Synonym Full Names: | hexamethylene bisacetamide inducible 2 |
NCBI Official Symbol: | HEXIM2 |
NCBI Official Synonym Symbols: | L3 |
NCBI Protein Information: | protein HEXIM2 |
UniProt Protein Name: | Protein HEXIM2 |
UniProt Synonym Protein Names: | Hexamethylene bis-acetamide-inducible protein 2 |
Protein Family: | Protein |
UniProt Gene Name: | HEXIM2 |
UniProt Entry Name: | HEXI2_HUMAN |