HERC6 Antibody, Biotin conjugated (PACO37737)
- SKU:
- PACO37737
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | HERC6 Antibody, Biotin conjugated (PACO37737) |
抗体コード: | PACO37737 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Probable E3 ubiquitin-protein ligase HERC6 protein (764-1022AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. |
シノニム: | Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6), HERC6 |
UniProt Protein Function: | HERC6: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 4q22.1 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:ligase activity; ubiquitin-protein ligase activity Biological Process: hemopoietic progenitor cell differentiation; protein ubiquitination during ubiquitin-dependent protein catabolic process |
NCBI Summary: | HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q8IVU3 |
NCBI GenInfo Identifier: | 259089405 |
NCBI Gene ID: | 55008 |
NCBI Accession: | NP_001158608.1 |
UniProt Secondary Accession: | Q8IVU3,Q5GC90, Q5GRH3, Q5HYM6, Q5JPB6, Q6PIF4, Q8NAN3 Q9NWS4, B4DIY5, |
UniProt Related Accession: | Q8IVU3 |
Molecular Weight: | 32,717 Da |
NCBI Full Name: | probable E3 ubiquitin-protein ligase HERC6 isoform 2 |
NCBI Synonym Full Names: | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
NCBI Official Symbol: | HERC6 |
NCBI Protein Information: | probable E3 ubiquitin-protein ligase HERC6 |
UniProt Protein Name: | Probable E3 ubiquitin-protein ligase HERC6 |
UniProt Synonym Protein Names: | HECT domain and RCC1-like domain-containing protein 6 |
Protein Family: | E3 ISG15--protein ligase |
UniProt Gene Name: | HERC6 |
UniProt Entry Name: | HERC6_HUMAN |