HAS2 Antibody, HRP conjugated (PACO45879)
- SKU:
- PACO45879
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | HAS2 Antibody, HRP conjugated (PACO45879) |
抗体コード: | PACO45879 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Hyaluronan synthase 2 protein (70-359AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). |
シノニム: | Hyaluronan synthase 2 (EC 2.4.1.212) (Hyaluronate synthase 2) (Hyaluronic acid, synthase 2) (HA synthase 2), HAS2 |
UniProt Protein Function: | HAS2: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Expressed in fibroblasts. Belongs to the nodC/HAS family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, multi-pass; Transferase; EC 2.4.1.212; Membrane protein, integral Chromosomal Location of Human Ortholog: 8q24.12 Cellular Component: integral to plasma membrane Molecular Function:hyaluronan synthase activity Biological Process: extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; positive regulation of cell proliferation; kidney development; vasculogenesis; positive regulation of cell migration |
NCBI Summary: | Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92819 |
NCBI GenInfo Identifier: | 4885391 |
NCBI Gene ID: | 3037 |
NCBI Accession: | NP_005319.1 |
UniProt Secondary Accession: | Q92819,Q32MM3, |
UniProt Related Accession: | Q92819 |
Molecular Weight: | 63566 |
NCBI Full Name: | hyaluronan synthase 2 |
NCBI Synonym Full Names: | hyaluronan synthase 2 |
NCBI Official Symbol: | HAS2 |
NCBI Protein Information: | hyaluronan synthase 2 |
UniProt Protein Name: | Hyaluronan synthase 2 |
UniProt Synonym Protein Names: | Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2 |
Protein Family: | Hyaluronan synthase |
UniProt Gene Name: | HAS2 |
UniProt Entry Name: | HYAS2_HUMAN |