GZMM Antibody, FITC conjugated (PACO51604)
- SKU:
- PACO51604
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | GZMM Antibody, FITC conjugated (PACO51604) |
抗体コード: | PACO51604 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Granzyme M protein (98-243AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. |
シノニム: | Granzyme M (EC 3.4.21) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease), GZMM, MET1 |
UniProt Protein Function: | GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzyme subfamily. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: membrane Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: cell death |
NCBI Summary: | Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
UniProt Code: | P51124 |
NCBI GenInfo Identifier: | 296434527 |
NCBI Gene ID: | 3004 |
NCBI Accession: | P51124.2 |
UniProt Related Accession: | P51124 |
Molecular Weight: | 27,545 Da |
NCBI Full Name: | Granzyme M |
NCBI Synonym Full Names: | granzyme M |
NCBI Official Symbol: | GZMM |
NCBI Official Synonym Symbols: | MET1; LMET1 |
NCBI Protein Information: | granzyme M |
UniProt Protein Name: | Granzyme M |
UniProt Synonym Protein Names: | Met-1 serine protease; Hu-Met-1; Met-ase; Natural killer cell granular protease |
Protein Family: | Granzyme |
UniProt Gene Name: | GZMM |
UniProt Entry Name: | GRAM_HUMAN |