GZMH Antibody (PACO44238)
- SKU:
- PACO44238
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GZMH Antibody (PACO44238) |
抗体コード: | PACO44238 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Granzyme H protein (20-246AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44238 at dilution of 1:100. |
![]() | Immunofluorescent analysis of PC-3 cells using PACO44238 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human thymus tissue using PACO44238 at dilution of 1:100. |
バックグラウンド: | Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acid, c residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. |
シノニム: | Granzyme H (EC 3.4.21.-) (CCP-X) (Cathepsin G-like 2) (CTSGL2) (Cytotoxic T-lymphocyte proteinase) (Cytotoxic serine protease C) (CSP-C), GZMH, CGL2 CTSGL2 |
UniProt Protein Function: | GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.21.- Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane Molecular Function:serine-type endopeptidase activity Biological Process: immune response; protein processing |
NCBI Summary: | This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015] |
UniProt Code: | P20718 |
NCBI GenInfo Identifier: | 121590 |
NCBI Gene ID: | 2999 |
NCBI Accession: | P20718.1 |
UniProt Secondary Accession: | P20718,Q6XGZ0, Q6XGZ1, G3V2C5, |
UniProt Related Accession: | P20718 |
Molecular Weight: | 12,609 Da |
NCBI Full Name: | Granzyme H |
NCBI Synonym Full Names: | granzyme H |
NCBI Official Symbol: | GZMH |
NCBI Official Synonym Symbols: | CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2 |
NCBI Protein Information: | granzyme H |
UniProt Protein Name: | Granzyme H |
UniProt Synonym Protein Names: | CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-C |
Protein Family: | Granzyme |
UniProt Gene Name: | GZMH |
UniProt Entry Name: | GRAH_HUMAN |