GRM3 Antibody, FITC conjugated (PACO63797)
- SKU:
- PACO63797
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | GRM3 Antibody, FITC conjugated (PACO63797) |
抗体コード: | PACO63797 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Metabotropic glutamate receptor 3 protein (46-354AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. |
シノニム: | Metabotropic glutamate receptor 3 (mGluR3), GRM3, GPRC1C MGLUR3 |
UniProt Protein Function: | mGluR3: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q21.1-q21.2 Cellular Component: presynaptic membrane; postsynaptic membrane; axon; integral to plasma membrane; postsynaptic density; dendritic spine; plasma membrane Molecular Function:G-protein coupled receptor activity; group II metabotropic glutamate receptor activity; group III metabotropic glutamate receptor activity; calcium channel regulator activity; glutamate receptor activity Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; negative regulation of adenylate cyclase activity; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway |
NCBI Summary: | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q14832 |
NCBI GenInfo Identifier: | 76803803 |
NCBI Gene ID: | 2913 |
NCBI Accession: | Q14832.2 |
UniProt Secondary Accession: | Q14832,Q2PNZ6, Q75MV4, Q75N17, Q86YG6, Q8TBH9, |
UniProt Related Accession: | Q14832 |
Molecular Weight: | 879 |
NCBI Full Name: | Metabotropic glutamate receptor 3 |
NCBI Synonym Full Names: | glutamate receptor, metabotropic 3 |
NCBI Official Symbol: | GRM3 |
NCBI Official Synonym Symbols: | GLUR3; mGlu3; GPRC1C; MGLUR3 |
NCBI Protein Information: | metabotropic glutamate receptor 3; glutamate metabotropic receptor 3 |
UniProt Protein Name: | Metabotropic glutamate receptor 3 |
Protein Family: | Metabotropic glutamate receptor |
UniProt Gene Name: | GRM3 |
UniProt Entry Name: | GRM3_HUMAN |