GRK4 Antibody (PACO27193)
- SKU:
- PACO27193
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GRK4 Antibody (PACO27193) |
抗体コード: | PACO27193 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human G protein-coupled receptor kinase 4 protein (1-245AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: GRK4 antibody at 2µg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 67, 64, 58, 62 kDa Observed band size: 67 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO27193 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO27193 at dilution of 1:100. |
バックグラウンド: | Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-α can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-α and GRK4-γ phosphorylate DRD3. Phosphorylates ADRB2. |
シノニム: | G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1), GRK4, GPRK2L GPRK4 |
UniProt Protein Function: | GRK4: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:AGC group; EC 2.7.11.16; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 4p16.3 Molecular Function:rhodopsin kinase activity Biological Process: receptor internalization; regulation of G-protein coupled receptor protein signaling pathway; regulation of rhodopsin mediated signaling |
NCBI Summary: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
UniProt Code: | P32298 |
NCBI GenInfo Identifier: | 143811400 |
NCBI Gene ID: | 2868 |
NCBI Accession: | P32298.3 |
UniProt Secondary Accession: | P32298,O00641, O00642, Q13293, Q13294, Q13295, Q14453 Q14725, Q15313, Q15314, Q15315, Q15316, |
UniProt Related Accession: | P32298 |
Molecular Weight: | 67kDa |
NCBI Full Name: | G protein-coupled receptor kinase 4 |
NCBI Synonym Full Names: | G protein-coupled receptor kinase 4 |
NCBI Official Symbol: | GRK4 |
NCBI Official Synonym Symbols: | IT11; GPRK4; GRK4a; GPRK2L |
NCBI Protein Information: | G protein-coupled receptor kinase 4 |
UniProt Protein Name: | G protein-coupled receptor kinase 4 |
UniProt Synonym Protein Names: | G protein-coupled receptor kinase GRK4; ITI1 |
Protein Family: | G protein-coupled receptor kinase |
UniProt Gene Name: | GRK4 |