GRK1 Antibody (PACO00886)
- SKU:
- PACO00886
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | GRK1 Antibody |
抗体コード: | PACO00886 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from human GRK 1 around the non-phosphorylation site of S21. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | GRK1; RHOK; Rhodopsin kinase; RK; G protein-coupled receptor kinase 1 |
UniProt Protein Function: | GRK1: a Ser/Thr of the GRK family. Phosphorylates and inactivates photon-activated rhodopsin. LOF mutations lead to type 2 Oguchi disease, a form of night blindness. A link between RHOK and retinitis pigmentosa is now thought to be unlikely |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.14; Kinase, protein; AGC group; GRK family; GRK subfamily Chromosomal Location of Human Ortholog: 13q34 Molecular Function:G-protein coupled receptor kinase activity; rhodopsin kinase activity; ATP binding; protein kinase activity Biological Process: rhodopsin mediated signaling; post-embryonic retina morphogenesis in camera-type eye; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; protein amino acid autophosphorylation; photoreceptor cell morphogenesis; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of phosphorylation; negative regulation of apoptosis Disease: Oguchi Disease 2 |
NCBI Summary: | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15835 |
NCBI GenInfo Identifier: | 2833269 |
NCBI Gene ID: | 6011 |
NCBI Accession: | Q15835.1 |
UniProt Secondary Accession: | Q15835,Q53X14, |
UniProt Related Accession: | Q15835 |
Molecular Weight: | 563 |
NCBI Full Name: | Rhodopsin kinase |
NCBI Synonym Full Names: | G protein-coupled receptor kinase 1 |
NCBI Official Symbol: | GRK1 |
NCBI Official Synonym Symbols: | RK; RHOK; GPRK1 |
NCBI Protein Information: | rhodopsin kinase |
UniProt Protein Name: | Rhodopsin kinase |
UniProt Synonym Protein Names: | G protein-coupled receptor kinase 1 |
UniProt Gene Name: | GRK1 |
UniProt Entry Name: | RK_HUMAN |