GRHPR Antibody (PACO51594)
- SKU:
- PACO51594
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GRHPR Antibody (PACO51594) |
抗体コード: | PACO51594 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human Glyoxylate reductase/hydroxypyruvate reductase protein (1-328AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat liver tissue, Mouse liver tissue. All lanes: GRHPR antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 36, 28 kDa. Observed band size: 36 kDa.. | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO51594 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver tissue using PACO51594 at dilution of 1:100. |
バックグラウンド: | Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. |
シノニム: | Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81), GRHPR, GLXR |
UniProt Protein Function: | GRHPR: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2); also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; Oxidoreductase; EC 1.1.1.79; EC 1.1.1.81 Chromosomal Location of Human Ortholog: 9q12 Cellular Component: peroxisomal matrix; cytoplasm; cytosol Molecular Function:glyoxylate reductase (NADP) activity; protein homodimerization activity; carboxylic acid binding; hydroxypyruvate reductase activity; NAD binding; glycerate dehydrogenase activity Biological Process: dicarboxylic acid metabolic process; glyoxylate metabolic process; metabolic process; excretion; protein oligomerization Disease: Hyperoxaluria, Primary, Type Ii |
NCBI Summary: | This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBQ7 |
NCBI GenInfo Identifier: | 47116943 |
NCBI Gene ID: | 9380 |
NCBI Accession: | Q9UBQ7.1 |
UniProt Related Accession: | Q9UBQ7 |
Molecular Weight: | |
NCBI Full Name: | Glyoxylate reductase/hydroxypyruvate reductase |
NCBI Synonym Full Names: | glyoxylate and hydroxypyruvate reductase |
NCBI Official Symbol: | GRHPR |
NCBI Official Synonym Symbols: | PH2; GLXR; GLYD |
NCBI Protein Information: | glyoxylate reductase/hydroxypyruvate reductase |
UniProt Protein Name: | Glyoxylate reductase/hydroxypyruvate reductase |
Protein Family: | Glyoxylate reductase/hydroxypyruvate reductase |
UniProt Gene Name: | GRHPR |
UniProt Entry Name: | GRHPR_HUMAN |