GRB14 Antibody (PACO00884)
- SKU:
- PACO00884
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GRB14 Antibody |
抗体コード: | PACO00884 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human GRB14. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | GRB14; Growth factor receptor-bound protein 14; GRB14 adapter protein |
UniProt Protein Function: | GRB14: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 2q22-q24 Cellular Component: Golgi membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; endosome membrane; cytosol Molecular Function:SH3/SH2 adaptor activity Biological Process: positive regulation of signal transduction; signal transduction; blood coagulation; leukocyte migration |
NCBI Summary: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | Q14449 |
NCBI GenInfo Identifier: | 59802920 |
NCBI Gene ID: | 2888 |
NCBI Accession: | Q14449.2 |
UniProt Secondary Accession: | Q14449,Q7Z6I1, B7Z7F9, |
UniProt Related Accession: | Q14449 |
Molecular Weight: | 540 |
NCBI Full Name: | Growth factor receptor-bound protein 14 |
NCBI Synonym Full Names: | growth factor receptor-bound protein 14 |
NCBI Official Symbol: | GRB14 |
NCBI Protein Information: | growth factor receptor-bound protein 14; GRB14 adapter protein |
UniProt Protein Name: | Growth factor receptor-bound protein 14 |
UniProt Synonym Protein Names: | GRB14 adapter protein |
Protein Family: | Growth factor receptor-bound protein |
UniProt Gene Name: | GRB14 |
UniProt Entry Name: | GRB14_HUMAN |