GRB10 Antibody, FITC conjugated (PACO54304)
- SKU:
- PACO54304
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | GRB10 Antibody, FITC conjugated (PACO54304) |
抗体コード: | PACO54304 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Growth factor receptor-bound protein 10 protein (15-180AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. |
シノニム: | Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR), GRB10, GRBIR KIAA0207 |
UniProt Protein Function: | GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7p12.2 Cellular Component: cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity; insulin receptor binding Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; positive regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; response to insulin stimulus; negative regulation of glycogen biosynthetic process |
NCBI Summary: | The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] |
UniProt Code: | Q13322 |
NCBI GenInfo Identifier: | 6166186 |
NCBI Gene ID: | 2887 |
NCBI Accession: | Q13322.2 |
UniProt Secondary Accession: | Q13322,O00427, O00701, O75222, Q92606, Q92907, Q92948 A4D258, A7VJ95, A8K0E6, D3DVM9, |
UniProt Related Accession: | Q13322 |
Molecular Weight: | 66,487 Da |
NCBI Full Name: | Growth factor receptor-bound protein 10 |
NCBI Synonym Full Names: | growth factor receptor-bound protein 10 |
NCBI Official Symbol: | GRB10 |
NCBI Official Synonym Symbols: | RSS; IRBP; MEG1; GRB-IR; Grb-10 |
NCBI Protein Information: | growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR |
UniProt Protein Name: | Growth factor receptor-bound protein 10 |
UniProt Synonym Protein Names: | GRB10 adapter protein; Insulin receptor-binding protein Grb-IR |
Protein Family: | Growth factor receptor-bound protein |
UniProt Gene Name: | GRB10 |
UniProt Entry Name: | GRB10_HUMAN |