GRAP2 Antibody (PACO51590)
- SKU:
- PACO51590
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GRAP2 Antibody (PACO51590) |
抗体コード: | PACO51590 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human GRB2-related adapter protein 2 protein (149-251AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat liver tissue. All lanes: GRAP2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38, 25 kDa. Observed band size: 38 kDa.. | |
Immunofluorescent analysis of Hela cells using PACO51590 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO51590 at dilution of 1:100. |
バックグラウンド: | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
シノニム: | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona), GRAP2, GADS GRB2L GRID |
UniProt Protein Function: | GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: cytoplasm; cytosol; endosome; nucleoplasm; nucleus Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: cell-cell signaling; innate immune response; positive regulation of signal transduction; Ras protein signal transduction; T cell costimulation; T cell receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
UniProt Code: | O75791 |
NCBI GenInfo Identifier: | 6685489 |
NCBI Gene ID: | 9402 |
NCBI Accession: | O75791.1 |
UniProt Secondary Accession: | O75791,O43726, Q9NRB7, B7Z8I3, |
UniProt Related Accession: | O75791 |
Molecular Weight: | 24,382 Da |
NCBI Full Name: | GRB2-related adapter protein 2 |
NCBI Synonym Full Names: | GRB2-related adaptor protein 2 |
NCBI Official Symbol: | GRAP2 |
NCBI Official Synonym Symbols: | P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2 |
NCBI Protein Information: | GRB2-related adapter protein 2 |
UniProt Protein Name: | GRB2-related adapter protein 2 |
UniProt Synonym Protein Names: | Adapter protein GRID; GRB-2-like protein; GRB2L; GRBLG; GRBX; Grf40 adapter protein; Grf-40; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; P38; Protein GADS; SH3-SH2-SH3 adapter Mona |
Protein Family: | GRB2-related adapter protein |
UniProt Gene Name: | GRAP2 |
UniProt Entry Name: | GRAP2_HUMAN |