UniProt Protein Function: | GPT: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. |
UniProt Protein Details: | Protein type:EC 2.6.1.2; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: cytosol Molecular Function:alanine transaminase activity Biological Process: amino acid biosynthetic process |
NCBI Summary: | This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009] |
UniProt Code: | P24298 |
NCBI GenInfo Identifier: | 46577683 |
NCBI Gene ID: | 2875 |
NCBI Accession: | P24298.3 |
UniProt Secondary Accession: | P24298,P78398, Q93076, B0YJ18, D3DWM7, |
UniProt Related Accession: | P24298 |
Molecular Weight: | 54,637 Da |
NCBI Full Name: | Alanine aminotransferase 1 |
NCBI Synonym Full Names: | glutamic--pyruvic transaminase |
NCBI Official Symbol: | GPT |
NCBI Official Synonym Symbols: | AAT1; ALT1; GPT1 |
NCBI Protein Information: | alanine aminotransferase 1 |
UniProt Protein Name: | Alanine aminotransferase 1 |
UniProt Synonym Protein Names: | Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1 |
Protein Family: | Alanine aminotransferase |
UniProt Gene Name: | GPT |
UniProt Entry Name: | ALAT1_HUMAN |