GPRC6A Antibody (PACO55958)
- SKU:
- PACO55958
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GPRC6A Antibody (PACO55958) |
抗体コード: | PACO55958 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:200-1:500, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human G-protein coupled receptor family C group 6 member A protein (403-581AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO55958 diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Western Blot. Positive WB detected in: HepG2 whole cell lysate, Hela whole cell lysate. All lanes: GPRC6A antibody at 4.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 105, 85, 97 kDa. Observed band size: 97 kDa. |
![]() | IHC image of PACO55958 diluted at 1:400 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Receptor activated by amino acid, with a preference for basic amino acid, such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acid,. The L-α amino acid, respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acid, , osteocalcin, divalent ions and its responsiveness to anabolic steroids. |
シノニム: | G-protein coupled receptor family C group 6 member A (hGPRC6A) (G-protein coupled receptor GPCR33) (hGPCR33), GPRC6A |
UniProt Protein Function: | GPRC6A: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 3; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 6q22.1 Cellular Component: plasma membrane Biological Process: response to amino acid stimulus |
NCBI Summary: | Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010] |
UniProt Code: | Q5T6X5 |
NCBI GenInfo Identifier: | 74745292 |
NCBI Gene ID: | 222545 |
NCBI Accession: | Q5T6X5.1 |
UniProt Secondary Accession: | Q5T6X5,Q6JK43, Q6JK44, Q8NGU8, Q8NHZ9, Q8TDT6, |
UniProt Related Accession: | Q5T6X5 |
Molecular Weight: | 96,526 Da |
NCBI Full Name: | G-protein coupled receptor family C group 6 member A |
NCBI Synonym Full Names: | G protein-coupled receptor class C group 6 member A |
NCBI Official Symbol: | GPRC6A |
NCBI Official Synonym Symbols: | GPCR; bA86F4.3 |
NCBI Protein Information: | G-protein coupled receptor family C group 6 member A |
UniProt Protein Name: | G-protein coupled receptor family C group 6 member A |
UniProt Synonym Protein Names: | G-protein coupled receptor GPCR33; hGPCR33 |
Protein Family: | G-protein coupled receptor family |
UniProt Gene Name: | GPRC6A |
UniProt Entry Name: | GPC6A_HUMAN |