GPR18 Antibody, Biotin conjugated (PACO35389)
- SKU:
- PACO35389
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | GPR18 Antibody, Biotin conjugated (PACO35389) |
抗体コード: | PACO35389 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human N-arachidonyl glycine receptor protein (290-331AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated by plant-derived and synthetic cannabinoid agonists. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaα and CD8alphaβ IELs)in small intstine by supporting preferential migration of CD8alphaα T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis. |
シノニム: | N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18), GPR18, GPCRW |
UniProt Protein Function: | GPR18: Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 13q32 Cellular Component: integral to membrane; plasma membrane Molecular Function:G-protein coupled receptor activity Biological Process: G-protein coupled receptor protein signaling pathway |
UniProt Code: | Q14330 |
NCBI GenInfo Identifier: | 148235349 |
NCBI Gene ID: | 2841 |
NCBI Accession: | NP_001091670.1 |
UniProt Secondary Accession: | Q14330,Q6GTM3, Q96HI6, Q9H2L2, |
UniProt Related Accession: | Q14330 |
Molecular Weight: | |
NCBI Full Name: | N-arachidonyl glycine receptor |
NCBI Synonym Full Names: | G protein-coupled receptor 18 |
NCBI Official Symbol: | GPR18 |
NCBI Protein Information: | N-arachidonyl glycine receptor |
UniProt Protein Name: | N-arachidonyl glycine receptor |
UniProt Synonym Protein Names: | G-protein coupled receptor 18 |
Protein Family: | N-arachidonyl glycine receptor |
UniProt Gene Name: | GPR18 |
UniProt Entry Name: | GPR18_HUMAN |