UniProt Protein Function: | G-beta 5: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:G protein, heterotrimeric beta Chromosomal Location of Human Ortholog: 15q21.2 Cellular Component: plasma membrane; nucleus Molecular Function:GTPase activity; G-protein gamma-subunit binding; signal transducer activity; protein binding; chaperone binding Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; metabolic process; signal transduction |
NCBI Summary: | Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14775 |
NCBI GenInfo Identifier: | 38258891 |
NCBI Gene ID: | 10681 |
NCBI Accession: | O14775.2 |
UniProt Secondary Accession: | O14775,Q9HAU9, Q9UFT3, B2RBR5, |
UniProt Related Accession: | O14775 |
Molecular Weight: | 395 |
NCBI Full Name: | Guanine nucleotide-binding protein subunit beta-5 |
NCBI Synonym Full Names: | guanine nucleotide binding protein (G protein), beta 5 |
NCBI Official Symbol: | GNB5 |
NCBI Official Synonym Symbols: | GB5 |
NCBI Protein Information: | guanine nucleotide-binding protein subunit beta-5; gbeta5; transducin beta chain 5; G protein, beta-5 subunit; G protein, beta subunit 5L; guanine nucleotide-binding protein, beta subunit 5L |
UniProt Protein Name: | Guanine nucleotide-binding protein subunit beta-5 |
UniProt Synonym Protein Names: | Gbeta5; Transducin beta chain 5 |
Protein Family: | Guanine nucleotide-binding protein |
UniProt Gene Name: | GNB5 |
UniProt Entry Name: | GBB5_HUMAN |