GNA11 Antibody (PACO48938)
- SKU:
- PACO48938
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | GNA11 Antibody (PACO48938) |
抗体コード: | PACO48938 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Guanine nucleotide-binding protein subunit alpha-11 protein (1-359AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO48938 at dilution of 1:100. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO48938 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. |
シノニム: | Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha), GNA11, GA11 |
UniProt Protein Function: | G-alpha 11: a guanine nucleotide-binding protein of the G-alpha family. Acts as an activator of phospholipase C. Involved in signaling of gonadotropin-releasing hormone receptor, negatively regulating cell growth. Down-regulation may be involved in human breast cancers. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. |
UniProt Protein Details: | Protein type:G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(q) Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex Molecular Function:GTPase activity; signal transducer activity; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; regulation of action potential; platelet activation; metabolic process; heart development; pigmentation during development; dopamine receptor, phospholipase C activating pathway; signal transduction; blood coagulation; skeletal development; regulation of melanocyte differentiation Disease: Hypocalciuric Hypercalcemia, Familial, Type Ii |
NCBI Summary: | The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013] |
UniProt Code: | P29992 |
NCBI GenInfo Identifier: | 3041682 |
NCBI Gene ID: | 2767 |
NCBI Accession: | P29992.2 |
UniProt Related Accession: | P29992 |
Molecular Weight: | ~42kDa |
NCBI Full Name: | Guanine nucleotide-binding protein subunit alpha-11 |
NCBI Synonym Full Names: | G protein subunit alpha 11 |
NCBI Official Symbol: | GNA11 |
NCBI Official Synonym Symbols: | FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2 |
NCBI Protein Information: | guanine nucleotide-binding protein subunit alpha-11 |
UniProt Protein Name: | Guanine nucleotide-binding protein subunit alpha-11 |
UniProt Synonym Protein Names: | Guanine nucleotide-binding protein G(y) subunit alpha |
Protein Family: | Guanine nucleotide-binding protein |
UniProt Gene Name: | GNA11 |
UniProt Entry Name: | GNA11_HUMAN |
Antibodies |
Anti-GNA11 Antibody (CAB2731) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |