GMPS Antibody (PACO09505)
- SKU:
- PACO09505
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GMPS Antibody (PACO09505) |
抗体コード: | PACO09505 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human GMPS |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | guanine monphosphate synthetase; |
UniProt Protein Function: | GMPS: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with MLL. |
UniProt Protein Details: | Protein type:Oncoprotein; Nucleotide Metabolism - purine; Xenobiotic Metabolism - drug metabolism - other enzymes; Ligase; EC 6.3.5.2 Chromosomal Location of Human Ortholog: 3q24 Cellular Component: cytoplasm; cytosol Molecular Function:GMP synthase (glutamine-hydrolyzing) activity; GMP synthase activity Biological Process: purine base biosynthetic process; purine ribonucleoside monophosphate biosynthetic process Disease: Leukemia, Acute Myeloid |
NCBI Summary: | In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008] |
UniProt Code: | P49915 |
NCBI GenInfo Identifier: | 1708072 |
NCBI Gene ID: | 8833 |
NCBI Accession: | P49915.1 |
UniProt Secondary Accession: | P49915,A8K639, B4DXV7, F8W720, |
UniProt Related Accession: | P49915 |
Molecular Weight: | 65,929 Da |
NCBI Full Name: | GMP synthase |
NCBI Synonym Full Names: | guanine monophosphate synthase |
NCBI Official Symbol: | GMPS |
NCBI Protein Information: | GMP synthase [glutamine-hydrolyzing] |
UniProt Protein Name: | GMP synthase [glutamine-hydrolyzing] |
UniProt Synonym Protein Names: | GMP synthetase; Glutamine amidotransferase |
UniProt Gene Name: | GMPS |
UniProt Entry Name: | GUAA_HUMAN |