GLP1R Antibody (PACO14467)
- SKU:
- PACO14467
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GLP1R Antibody (PACO14467) |
抗体コード: | PACO14467 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human GLP1R |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14467(GLP1R Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using PACO14467(GLP1R Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The glucagon-like peptide 1 receptor (GLP1R) is a human gene which resides on chromosome 6.The protein encoded by this gene is a member of the glucagon receptor family of G protein-coupled receptors. GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic β cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently GLP1R has been suggested as a potential target for the treatment of diabetes. |
シノニム: | glucagon-like peptide 1 receptor |
UniProt Protein Function: | GLP1R: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2 Chromosomal Location of Human Ortholog: 6p21 Cellular Component: cytosol; integral to membrane; intracellular; plasma membrane Molecular Function:glucagon receptor activity; protein binding; transmembrane receptor activity Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; learning and/or memory; positive regulation of blood pressure; regulation of heart contraction; regulation of insulin secretion; response to stress |
NCBI Summary: | This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016] |
UniProt Code: | P43220 |
NCBI GenInfo Identifier: | 311033387 |
NCBI Gene ID: | 2740 |
NCBI Accession: | P43220.2 |
UniProt Secondary Accession: | P43220,Q2M229, Q99669, |
UniProt Related Accession: | P43220 |
Molecular Weight: | |
NCBI Full Name: | Glucagon-like peptide 1 receptor |
NCBI Synonym Full Names: | glucagon like peptide 1 receptor |
NCBI Official Symbol: | GLP1R |
NCBI Official Synonym Symbols: | GLP-1; GLP-1R; GLP-1-R |
NCBI Protein Information: | glucagon-like peptide 1 receptor |
UniProt Protein Name: | Glucagon-like peptide 1 receptor |
Protein Family: | Glucagon-like peptide 1 receptor |
UniProt Gene Name: | GLP1R |
UniProt Entry Name: | GLP1R_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |