UniProt Protein Function: | GLO1: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Belongs to the glyoxalase I family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase Chromosomal Location of Human Ortholog: 6p21.3-p21.1 Cellular Component: cytoplasm Molecular Function:zinc ion binding; lactoylglutathione lyase activity Biological Process: regulation of transcription from RNA polymerase II promoter; glutathione metabolic process; carbohydrate metabolic process; osteoclast differentiation; methylglyoxal metabolic process; negative regulation of apoptosis Disease: Autism |
NCBI Summary: | The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q04760 |
NCBI GenInfo Identifier: | 134039205 |
NCBI Gene ID: | 2739 |
NCBI Accession: | Q04760.4 |
UniProt Secondary Accession: | Q04760,P78375, Q59EL0, Q5TZW3, Q96FC0, Q96J41, B2R6P7 B4DDV0, |
UniProt Related Accession: | Q04760 |
Molecular Weight: | Calculated: 19kDa/20kDaObserved: 21kDa |
NCBI Full Name: | Lactoylglutathione lyase |
NCBI Synonym Full Names: | glyoxalase I |
NCBI Official Symbol: | GLO1 |
NCBI Official Synonym Symbols: | GLYI; GLOD1; HEL-S-74 |
NCBI Protein Information: | lactoylglutathione lyase; glx I; aldoketomutase; methylglyoxalase; ketone-aldehyde mutase; lactoyl glutathione lyase; glyoxalase domain containing 1; epididymis secretory protein Li 74; S-D-lactoylglutathione methylglyoxal lyase |
UniProt Protein Name: | Lactoylglutathione lyase |
UniProt Synonym Protein Names: | Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase |
UniProt Gene Name: | GLO1 |
UniProt Entry Name: | LGUL_HUMAN |