GLMN Antibody (PACO19712)
- SKU:
- PACO19712
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GLMN Antibody (PACO19712) |
抗体コード: | PACO19712 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Synthetic peptide of human GLMN |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19712(GLMN Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19712(GLMN Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. |
シノニム: | glomulin, FKBP associated protein |
UniProt Protein Function: | GLMN: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. Defects in GLMN are the cause of glomuvenous malformations (GVMs). GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 1p22.1 Cellular Component: Cul2-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex Molecular Function:hepatocyte growth factor receptor binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase inhibitor activity Biological Process: muscle cell differentiation; negative regulation of T cell proliferation; positive regulation of cytokine secretion; positive regulation of interleukin-2 biosynthetic process; positive regulation of phosphorylation; regulation of gene expression, epigenetic; regulation of proteasomal ubiquitin-dependent protein catabolic process; vasculogenesis Disease: Glomuvenous Malformations |
NCBI Summary: | This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] |
UniProt Code: | Q92990 |
NCBI GenInfo Identifier: | 38372884 |
NCBI Gene ID: | 11146 |
NCBI Accession: | Q92990.2 |
UniProt Secondary Accession: | Q92990,Q5VVC3, Q9BVE8, |
UniProt Related Accession: | Q92990 |
Molecular Weight: | 48,166 Da |
NCBI Full Name: | Glomulin |
NCBI Synonym Full Names: | glomulin, FKBP associated protein |
NCBI Official Symbol: | GLMN |
NCBI Official Synonym Symbols: | FAP; GVM; GLML; FAP48; FAP68; FKBPAP; VMGLOM |
NCBI Protein Information: | glomulin |
UniProt Protein Name: | Glomulin |
UniProt Synonym Protein Names: | FK506-binding protein-associated protein; FAP; FKBP-associated protein |
Protein Family: | Glomulin |
UniProt Gene Name: | GLMN |
UniProt Entry Name: | GLMN_HUMAN |
Antibodies |
Anti-GLMN Antibody (CAB12025) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |