UniProt Protein Function: | GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: plasma membrane Molecular Function:transmembrane receptor activity Biological Process: adenylate cyclase activation; generation of precursor metabolites and energy; regulation of insulin secretion; response to nutrient |
NCBI Summary: | This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011] |
UniProt Code: | P48546 |
NCBI GenInfo Identifier: | 1346133 |
NCBI Gene ID: | 2696 |
NCBI Accession: | P48546.1 |
UniProt Secondary Accession: | P48546,Q14401, Q16400, Q52M04, Q9UPI1, B7WP14, B7ZKQ0 |
UniProt Related Accession: | P48546 |
Molecular Weight: | 49,062 Da |
NCBI Full Name: | Gastric inhibitory polypeptide receptor |
NCBI Synonym Full Names: | gastric inhibitory polypeptide receptor |
NCBI Official Symbol: | GIPR |
NCBI Official Synonym Symbols: | PGQTL2 |
NCBI Protein Information: | gastric inhibitory polypeptide receptor |
UniProt Protein Name: | Gastric inhibitory polypeptide receptor |
UniProt Synonym Protein Names: | Glucose-dependent insulinotropic polypeptide receptor |
Protein Family: | Gastric inhibitory polypeptide receptor |
UniProt Gene Name: | GIPR |
UniProt Entry Name: | GIPR_HUMAN |