GGCT Antibody (PACO60713)
- SKU:
- PACO60713
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GGCT Antibody (PACO60713) |
抗体コード: | PACO60713 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human Gamma-glutamylcyclotransferase protein (54-188AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO60713 diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO60713 diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. |
シノニム: | Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21), GGCT, C7orf24 CRF21 |
UniProt Protein Function: | GGCT: Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Belongs to the gamma-glutamylcyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 2.3.2.4; Transferase; Apoptosis; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 7p15-p14 Cellular Component: cytosol Molecular Function:gamma-glutamylcyclotransferase activity; protein homodimerization activity Biological Process: glutathione biosynthetic process; release of cytochrome c from mitochondria |
NCBI Summary: | The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | O75223 |
NCBI GenInfo Identifier: | 34222503 |
NCBI Gene ID: | 79017 |
NCBI Accession: | O75223.1 |
UniProt Secondary Accession: | O75223,Q9BS37, B2RDN0, B8ZZN4, B8ZZR8, |
UniProt Related Accession: | O75223 |
Molecular Weight: | 19,092 Da |
NCBI Full Name: | Gamma-glutamylcyclotransferase |
NCBI Synonym Full Names: | gamma-glutamylcyclotransferase |
NCBI Official Symbol: | GGCT |
NCBI Official Synonym Symbols: | GGC; GCTG; CRF21; C7orf24 |
NCBI Protein Information: | gamma-glutamylcyclotransferase |
UniProt Protein Name: | Gamma-glutamylcyclotransferase |
UniProt Synonym Protein Names: | Cytochrome c-releasing factor 21 |
Protein Family: | Gamma-glutamylcyclotransferase |
UniProt Gene Name: | GGCT |
UniProt Entry Name: | GGCT_HUMAN |
Antibodies | ELISA Kits |
Anti-GGCT Antibody (CAB4957) | Human GGCT (Gamma-glutamylcyclotransferase) ELISA Kit (HUFI04134) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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