| UniProt Protein Function: | GGA3: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200. Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Ubiquitously expressed. Belongs to the GGA protein family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Vesicle; Adaptor/scaffoldChromosomal Location of Human Ortholog: 17q25.1Cellular Component: clathrin adaptor complex; endosome membrane; trans-Golgi networkMolecular Function: ADP-ribosylation factor binding; protein bindingBiological Process: vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q9NZ52 |
| NCBI GenInfo Identifier: | 289577109 |
| NCBI Gene ID: | 23163 |
| NCBI Accession: | NP_001166174.1 |
| UniProt Secondary Accession: | Q9NZ52,Q15017, Q6IS16, Q9UJY3, B7Z7E2, B7Z7M9, J3KRN0 |
| UniProt Related Accession: | Q9NZ52 |
| Molecular Weight: | 70,148 Da |
| NCBI Full Name: | ADP-ribosylation factor-binding protein GGA3 isoform 1 |
| NCBI Synonym Full Names: | golgi-associated, gamma adaptin ear containing, ARF binding protein 3 |
| NCBI Official Symbol: | GGA3 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | ADP-ribosylation factor-binding protein GGA3 |
| UniProt Protein Name: | ADP-ribosylation factor-binding protein GGA3 |
| UniProt Synonym Protein Names: | Golgi-localized, gamma ear-containing, ARF-binding protein 3 |
| Protein Family: | ADP-ribosylation factor-binding protein |
| UniProt Gene Name: | GGA3 |
| UniProt Entry Name: | GGA3_HUMAN |
