GFER Antibody (PACO14017)
- SKU:
- PACO14017
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GFER Antibody (PACO14017) |
抗体コード: | PACO14017 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human GFER |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO14017(GFER Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14017(GFER Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42 similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. |
シノニム: | growth factor, augmenter of liver regeneration |
UniProt Protein Function: | GFER: Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD); also called combined mitochondrial complex deficiency. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial; EC 1.8.3.2; Oxidoreductase Chromosomal Location of Human Ortholog: 16p13.3-p13.12 Cellular Component: cytoplasm; mitochondrion Molecular Function:FAD binding; protein binding; protein disulfide oxidoreductase activity Disease: Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay |
NCBI Summary: | The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P55789 |
NCBI GenInfo Identifier: | 218511915 |
NCBI Gene ID: | 2671 |
NCBI Accession: | P55789.2 |
UniProt Secondary Accession: | P55789,Q53YM6, Q8TAH6, Q9H290, Q9UK40, |
UniProt Related Accession: | P55789 |
Molecular Weight: | 15,029 Da |
NCBI Full Name: | FAD-linked sulfhydryl oxidase ALR |
NCBI Synonym Full Names: | growth factor, augmenter of liver regeneration |
NCBI Official Symbol: | GFER |
NCBI Official Synonym Symbols: | ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1 |
NCBI Protein Information: | FAD-linked sulfhydryl oxidase ALR |
UniProt Protein Name: | FAD-linked sulfhydryl oxidase ALR |
UniProt Synonym Protein Names: | Augmenter of liver regeneration; hERV1; Hepatopoietin |
Protein Family: | FAD-linked sulfhydryl oxidase |
UniProt Gene Name: | GFER |
UniProt Entry Name: | ALR_HUMAN |