GEMIN6 Antibody, Biotin conjugated (PACO38385)
- SKU:
- PACO38385
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | GEMIN6 Antibody, Biotin conjugated (PACO38385) |
抗体コード: | PACO38385 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Gem-associated protein 6 protein (1-167AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. |
シノニム: | Gem-associated protein 6 (Gemin-6) (SIP2), GEMIN6 |
UniProt Protein Function: | GEMIN6: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. |
UniProt Protein Details: | Protein type:RNA splicing Chromosomal Location of Human Ortholog: 2p22.1 Cellular Component: cytoplasm; cytosol; nuclear body; nucleoplasm; SMN complex Molecular Function:protein binding Biological Process: nuclear import; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis |
NCBI Summary: | GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002] |
UniProt Code: | Q8WXD5 |
NCBI GenInfo Identifier: | 34921901 |
NCBI Gene ID: | 79833 |
NCBI Accession: | Q8WXD5.1 |
UniProt Secondary Accession: | Q8WXD5,Q53SI5, Q8WVB4, Q9H5G6, B2RDP8, |
UniProt Related Accession: | Q8WXD5 |
Molecular Weight: | 19kDa |
NCBI Full Name: | Gem-associated protein 6 |
NCBI Synonym Full Names: | gem nuclear organelle associated protein 6 |
NCBI Official Symbol: | GEMIN6 |
NCBI Protein Information: | gem-associated protein 6 |
UniProt Protein Name: | Gem-associated protein 6 |
UniProt Synonym Protein Names: | SIP2 |
Protein Family: | Gem-associated protein |
UniProt Gene Name: | GEMIN6 |