GDF3 Antibody (PACO63883)
- SKU:
- PACO63883
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GDF3 Antibody (PACO63883) |
抗体コード: | PACO63883 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Peptide sequence from Human Growth/differentiation factor 3 protein (202-222AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of HepG2 cells with PACO63883 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto. |
シノニム: | Growth/differentiation factor 3 (GDF-3), GDF3 |
UniProt Protein Function: | GDF3: Defects in GDF3 are the cause of Klippel-Feil syndrome type 3 (KFS3); also called Klippel-Feil syndrome autosomal dominant 3. KFS3 is a skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Defects in GDF3 are the cause of microphthalmia isolated with coloboma type 6 (MCOPCB6); also called isolated colobomatous microphthalmia 6. MCOPCB6 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Defects in GDF3 are a cause of microphthalmia isolated type 7 (MCOP7). MCOP7 is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Cytokine; Secreted Chromosomal Location of Human Ortholog: 12p13.1 Cellular Component: cytoplasm; extracellular space Molecular Function:cytokine activity; protein kinase binding; transforming growth factor beta receptor binding Biological Process: cell development; eye development; negative regulation of BMP signaling pathway; negative regulation of epidermal cell differentiation; regulation of apoptosis; regulation of cell fate commitment; regulation of MAPKKK cascade; skeletal development Disease: Klippel-feil Syndrome 3, Autosomal Dominant; Microphthalmia, Isolated 7; Microphthalmia, Isolated, With Coloboma 6 |
NCBI Summary: | The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NR23 |
NCBI GenInfo Identifier: | 46397885 |
NCBI Gene ID: | 9573 |
NCBI Accession: | Q9NR23.3 |
UniProt Secondary Accession: | Q9NR23,Q8NEJ4, |
UniProt Related Accession: | Q9NR23 |
Molecular Weight: | 41,387 Da |
NCBI Full Name: | Growth/differentiation factor 3 |
NCBI Synonym Full Names: | growth differentiation factor 3 |
NCBI Official Symbol: | GDF3 |
NCBI Official Synonym Symbols: | KFS3; MCOP7; MCOPCB6 |
NCBI Protein Information: | growth/differentiation factor 3 |
UniProt Protein Name: | Growth/differentiation factor 3 |
Protein Family: | Growth/differentiation factor |
UniProt Gene Name: | GDF3 |
UniProt Entry Name: | GDF3_HUMAN |
Antibodies | ELISA Kits |
Anti-GDF3 Antibody (CAB2738) | Human GDF3 ELISA Kit |
GDF3 Antibody (PACO06922) | Human GDF3 (Growth Differentiation Factor 3) CLIA Kit (HUES01055) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |