GCGR Antibody, HRP conjugated (PACO48343)
- SKU:
- PACO48343
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | GCGR Antibody, HRP conjugated (PACO48343) |
抗体コード: | PACO48343 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Glucagon receptor protein (26-136AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. |
シノニム: | Glucagon receptor (GL-R), GCGR |
UniProt Protein Function: | GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR Chromosomal Location of Human Ortholog: 17q25 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:glucagon receptor activity; guanyl-nucleotide exchange factor activity Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; generation of precursor metabolites and energy; glucose homeostasis; regulation of blood pressure; response to nutrient; response to starvation Disease: Diabetes Mellitus, Noninsulin-dependent |
NCBI Summary: | The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010] |
UniProt Code: | P47871 |
NCBI GenInfo Identifier: | 1346144 |
NCBI Gene ID: | 2642 |
NCBI Accession: | P47871.1 |
UniProt Secondary Accession: | P47871,Q2M3M5, |
UniProt Related Accession: | P47871 |
Molecular Weight: | 54,009 Da |
NCBI Full Name: | Glucagon receptor |
NCBI Synonym Full Names: | glucagon receptor |
NCBI Official Symbol: | GCGR |
NCBI Official Synonym Symbols: | GGR; GL-R |
NCBI Protein Information: | glucagon receptor |
UniProt Protein Name: | Glucagon receptor |
Protein Family: | Glucagon receptor |
UniProt Gene Name: | GCGR |
UniProt Entry Name: | GLR_HUMAN |