GABRB1 (Ab-434) Antibody (PACO21394)
- SKU:
- PACO21394
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GABRB1 (Ab-434) Antibody (PACO21394) |
抗体コード: | PACO21394 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Peptide sequence around aa.432~436 (R-A-S-Q-L) derived from Human GABRB1. |
憲法: | Liquid |
ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from PC12 cells using GABRB1(Ab-434) Antibody and the same antibody preincubated with blocking peptide. |
バックグラウンド: | The gamma-aminobutyric acid, (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, β 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding a 4, a 2 and γ 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. Ma DQ, et al. (2005) Am J Hum Genet ;77(3):377-388. |
シノニム: | GABA(A) receptor; GABA(A)R beta-1; GBRB1; GABA-RB; |
UniProt Protein Function: | GABRB1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily. |
UniProt Protein Details: | Protein type:Channel, chloride; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ion channel; Channel, ligand-gated Chromosomal Location of Human Ortholog: 4p12 Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction Molecular Function:chloride channel activity; GABA-A receptor activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity Biological Process: synaptic transmission; transport; ion transport; signal transduction; transmembrane transport |
NCBI Summary: | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008] |
UniProt Code: | P18505 |
NCBI GenInfo Identifier: | 194097327 |
NCBI Gene ID: | 2560 |
NCBI Accession: | NP_000803.2 |
UniProt Related Accession: | P18505 |
Molecular Weight: | ~ 54kDa |
NCBI Full Name: | gamma-aminobutyric acid receptor subunit beta-1 |
NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor subunit beta1 |
NCBI Official Symbol: | GABRB1 |
NCBI Official Synonym Symbols: | EIEE45 |
NCBI Protein Information: | gamma-aminobutyric acid receptor subunit beta-1 |
UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit beta-1 |
UniProt Synonym Protein Names: | GABA(A) receptor subunit beta-1 |
UniProt Gene Name: | GABRB1 |
UniProt Entry Name: | GBRB1_HUMAN |
Antibodies |
Anti-GABRB1 Antibody (CAB16015) |
Phospho-GABRB1 (S434) Antibody (PACO00289) |
GABRB1 Antibody (PACO03779) |
GABRB1 Antibody (PACO09387) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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