GABBR2 Antibody (PACO05782)
- SKU:
- PACO05782
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | GABBR2 Antibody (PACO05782) |
抗体コード: | PACO05782 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:10000, WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from human GABAB R2 around the non-phosphorylation site of S893. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | GABBR2; GPR51; GPRC3B; γ-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20 |
UniProt Protein Function: | GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. |
UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q22.1-q22.3 Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; cell junction Molecular Function:protein binding; GABA-B receptor activity Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; negative regulation of adenylate cyclase activity; gamma-aminobutyric acid signaling pathway Disease: Tobacco Addiction, Susceptibility To |
NCBI Summary: | The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010] |
UniProt Code: | O75899 |
NCBI GenInfo Identifier: | 12643641 |
NCBI Gene ID: | 9568 |
NCBI Accession: | O75899.1 |
UniProt Secondary Accession: | O75899,O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1 Q9UNS9, |
UniProt Related Accession: | O75899 |
Molecular Weight: | 941 |
NCBI Full Name: | Gamma-aminobutyric acid type B receptor subunit 2 |
NCBI Synonym Full Names: | gamma-aminobutyric acid (GABA) B receptor, 2 |
NCBI Official Symbol: | GABBR2 |
NCBI Official Synonym Symbols: | HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099 |
NCBI Protein Information: | gamma-aminobutyric acid type B receptor subunit 2; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coupled receptor 51; G-protein coupled receptor 51; gamma-aminobutyric acid B receptor 2 |
UniProt Protein Name: | Gamma-aminobutyric acid type B receptor subunit 2 |
UniProt Synonym Protein Names: | G-protein coupled receptor 51; HG20 |
Protein Family: | Gamma-aminobutyric acid type B receptor |
UniProt Gene Name: | GABBR2 |
UniProt Entry Name: | GABR2_HUMAN |