GABARAPL1 Antibody, FITC conjugated (PACO50992)
- SKU:
- PACO50992
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | GABARAPL1 Antibody, FITC conjugated (PACO50992) |
抗体コード: | PACO50992 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Gamma-aminobutyric acid, receptor-associated protein-like 1 protein (1-117AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. |
シノニム: | Gamma-aminobutyric acid, receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1), GABARAPL1, GEC1 |
UniProt Protein Function: | GABARAPL1: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Belongs to the MAP1 LC3 family. Interacts with GABRG2 and beta-tubulin. Interacts with KOR-1. |
UniProt Protein Details: | Protein type:Vesicle; Adaptor/scaffold; Microtubule-binding; Autophagy; Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 12p13.2 Cellular Component: autophagic vacuole; cytoplasmic vesicle membrane; cytosol; dendrite cytoplasm; endoplasmic reticulum; Golgi apparatus; intracellular; microtubule; mitochondrion Molecular Function:beta-tubulin binding; GABA receptor binding; protein binding; Tat protein binding; ubiquitin protein ligase binding Biological Process: autophagic vacuole formation; cellular response to nitrogen starvation; macroautophagy; mitochondrion degradation |
UniProt Code: | Q9H0R8 |
NCBI GenInfo Identifier: | 13899219 |
NCBI Gene ID: | 23710 |
NCBI Accession: | NP_113600.1 |
UniProt Secondary Accession: | Q9H0R8,Q6FIE6, B4E0Y7, |
UniProt Related Accession: | Q9H0R8 |
Molecular Weight: | 17,008 Da |
NCBI Full Name: | gamma-aminobutyric acid receptor-associated protein-like 1 |
NCBI Synonym Full Names: | GABA type A receptor associated protein like 1 |
NCBI Official Symbol: | GABARAPL1 |
NCBI Official Synonym Symbols: | ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE |
NCBI Protein Information: | gamma-aminobutyric acid receptor-associated protein-like 1 |
UniProt Protein Name: | Gamma-aminobutyric acid receptor-associated protein-like 1 |
UniProt Synonym Protein Names: | Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1 |
Protein Family: | Gamma-aminobutyric acid receptor-associated protein |
UniProt Gene Name: | GABARAPL1 |
UniProt Entry Name: | GBRL1_HUMAN |