GAB2 Antibody, HRP conjugated (PACO52907)
- SKU:
- PACO52907
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | GAB2 Antibody, HRP conjugated (PACO52907) |
抗体コード: | PACO52907 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human GRB2-associated-binding protein 2 protein (273-484AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
シノニム: | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100), GAB2, KIAA0571 |
UniProt Protein Function: | GAB2: an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: cytoplasm; cytosol; plasma membrane Molecular Function:phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity Biological Process: osteoclast differentiation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation |
NCBI Summary: | This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] |
UniProt Code: | Q9UQC2 |
NCBI GenInfo Identifier: | 46396035 |
NCBI Gene ID: | 9846 |
NCBI Accession: | Q9UQC2.1 |
UniProt Secondary Accession: | Q9UQC2,O60317, A2RRM2, A6NEW9, A7MD36, |
UniProt Related Accession: | Q9UQC2 |
Molecular Weight: | 69,968 Da |
NCBI Full Name: | GRB2-associated-binding protein 2 |
NCBI Synonym Full Names: | GRB2 associated binding protein 2 |
NCBI Official Symbol: | GAB2 |
NCBI Protein Information: | GRB2-associated-binding protein 2 |
UniProt Protein Name: | GRB2-associated-binding protein 2 |
UniProt Synonym Protein Names: | GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100 |
Protein Family: | GRB2-associated-binding protein |
UniProt Gene Name: | GAB2 |
UniProt Entry Name: | GAB2_HUMAN |