G6PC Antibody, FITC conjugated (PACO26871)
- SKU:
- PACO26871
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | G6PC Antibody, FITC conjugated (PACO26871) |
抗体コード: | PACO26871 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Glucose-6-phosphatase protein (82-117AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. |
シノニム: | Glucose-6-phosphatase (G-6-Pase) (G6Pase) (EC 3.1.3.9) (Glucose-6-phosphatase alpha) (G6Pase-alpha), G6PC, G6PT |
UniProt Protein Function: | G6PC: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A). A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Belongs to the glucose-6-phosphatase family.Protein type: Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral; Endoplasmic reticulum; EC 3.1.3.9Chromosomal Location of Human Ortholog: 17q21Cellular Component: endoplasmic reticulum membrane; integral to membrane; integral to endoplasmic reticulum membraneMolecular Function: glucose-6-phosphatase activity; phosphate binding; phosphotransferase activity, alcohol group as acceptorBiological Process: steroid metabolic process; response to food; glycogen metabolic process; phosphorylated carbohydrate dephosphorylation; glycogen catabolic process; multicellular organism growth; glucose 6-phosphate metabolic process; pathogenesis; glucose transport; glucose homeostasis; gluconeogenesis; cholesterol homeostasis; triacylglycerol metabolic process; urate metabolic process; glucose-6-phosphate transport; regulation of gene expression; hexose transport; carbohydrate metabolic process; transmembrane transportDisease: Glycogen Storage Disease Ia |
UniProt Protein Details: | |
NCBI Summary: | Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011] |
UniProt Code: | P35575 |
NCBI GenInfo Identifier: | 206729864 |
NCBI Gene ID: | 2538 |
NCBI Accession: | P35575.2 |
UniProt Secondary Accession: | P35575,A1L4C0, B4E1C3, K7EL82 |
UniProt Related Accession: | P35575 |
Molecular Weight: | 20,209 Da |
NCBI Full Name: | Glucose-6-phosphatase |
NCBI Synonym Full Names: | glucose-6-phosphatase, catalytic subunit |
NCBI Official Symbol: | G6PC |
NCBI Official Synonym Symbols: | G6PT; GSD1; G6PC1; GSD1a |
NCBI Protein Information: | glucose-6-phosphatase; G6Pase; G-6-Pase; G6Pase-alpha; glucose-6-phosphatase alpha |
UniProt Protein Name: | Glucose-6-phosphatase |
UniProt Synonym Protein Names: | Glucose-6-phosphatase alpha; G6Pase-alpha |
Protein Family: | Glucose-6-phosphatase |
UniProt Gene Name: | G6PC |
UniProt Entry Name: | G6PC_HUMAN |