UniProt Protein Function: | FUT1: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values. Belongs to the glycosyltransferase 11 family. |
UniProt Protein Details: | Protein type:Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.69; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: Golgi apparatus; integral to plasma membrane; membrane Molecular Function:fucosyltransferase activity; galactoside 2-alpha-L-fucosyltransferase activity Biological Process: carbohydrate metabolic process; protein amino acid glycosylation |
NCBI Summary: | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Jul 2008] |
UniProt Code: | P19526 |
NCBI GenInfo Identifier: | 120636 |
NCBI Gene ID: | 2523 |
NCBI Accession: | P19526.1 |
UniProt Secondary Accession: | P19526,O14505, O14506, O14507, |
UniProt Related Accession: | P19526 |
Molecular Weight: | 41,251 Da |
NCBI Full Name: | Galactoside 2-alpha-L-fucosyltransferase 1 |
NCBI Synonym Full Names: | fucosyltransferase 1 (H blood group) |
NCBI Official Symbol: | FUT1 |
NCBI Official Synonym Symbols: | H; HH; HSC |
NCBI Protein Information: | galactoside 2-alpha-L-fucosyltransferase 1 |
UniProt Protein Name: | Galactoside 2-alpha-L-fucosyltransferase 1 |
UniProt Synonym Protein Names: | Alpha(1,2)FT 1; Blood group H alpha 2-fucosyltransferase; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 |
Protein Family: | Galactoside 2-alpha-L-fucosyltransferase |
UniProt Gene Name: | FUT1 |
UniProt Entry Name: | FUT1_HUMAN |