FNIP1 Antibody, FITC conjugated (PACO46812)
- SKU:
- PACO46812
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | FNIP1 Antibody, FITC conjugated (PACO46812) |
抗体コード: | PACO46812 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Folliculin-interacting protein 1 protein (221-508AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. |
シノニム: | Folliculin-interacting protein 1, FNIP1, KIAA1961 |
UniProt Protein Function: | FNIP1: May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Belongs to the FNIP family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: cytoplasm Molecular Function:ATPase inhibitor activity; chaperone binding; guanyl-nucleotide exchange factor activity; protein binding Biological Process: cellular response to starvation; immature B cell differentiation; negative regulation of caspase activity; negative regulation of TOR signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein complex assembly; regulation of protein amino acid phosphorylation; TOR signaling pathway |
NCBI Summary: | This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 2, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity. [provided by RefSeq, Sep 2016] |
UniProt Code: | Q8TF40 |
NCBI GenInfo Identifier: | 1070257753 |
NCBI Gene ID: | 96459 |
NCBI Accession: | NP_001333043.1 |
UniProt Secondary Accession: | Q8TF40,Q86T47, Q9BUT0, D6RJH5, |
UniProt Related Accession: | Q8TF40 |
Molecular Weight: | 127,444 Da |
NCBI Full Name: | folliculin-interacting protein 1 isoform 4 |
NCBI Synonym Full Names: | folliculin interacting protein 1 |
NCBI Official Symbol: | FNIP1 |
NCBI Protein Information: | folliculin-interacting protein 1 |
UniProt Protein Name: | Folliculin-interacting protein 1 |
Protein Family: | Folliculin-interacting protein |
UniProt Gene Name: | FNIP1 |