FIS1 Antibody, Biotin conjugated (PACO47421)
- SKU:
- PACO47421
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | FIS1 Antibody, Biotin conjugated (PACO47421) |
抗体コード: | PACO47421 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Mitochondrial fission 1 protein (1-122AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. |
シノニム: | Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11), FIS1, TTC11 |
UniProt Protein Function: | FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. |
UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to mitochondrial outer membrane; integral to peroxisomal membrane; membrane; mitochondrion; peroxisome; protein complex Molecular Function:protein binding; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; mitochondrion degradation; peroxisome fission; positive regulation of caspase activity; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria |
NCBI Summary: | The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9Y3D6 |
NCBI GenInfo Identifier: | 33112470 |
NCBI Gene ID: | 51024 |
NCBI Accession: | Q9Y3D6.2 |
UniProt Secondary Accession: | Q9Y3D6,Q9BTP3, |
UniProt Related Accession: | Q9Y3D6 |
Molecular Weight: | 16,938 Da |
NCBI Full Name: | Mitochondrial fission 1 protein |
NCBI Synonym Full Names: | fission, mitochondrial 1 |
NCBI Official Symbol: | FIS1 |
NCBI Official Synonym Symbols: | TTC11; CGI-135 |
NCBI Protein Information: | mitochondrial fission 1 protein |
UniProt Protein Name: | Mitochondrial fission 1 protein |
UniProt Synonym Protein Names: | FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11 |
Protein Family: | Mitochondria fission 1 protein |
UniProt Gene Name: | FIS1 |
UniProt Entry Name: | FIS1_HUMAN |