FGF18 Antibody (PACO05626)
- SKU:
- PACO05626
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | FGF18 Antibody (PACO05626) |
抗体コード: | PACO05626 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:40000, IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the C-terminal region of human FGF-18. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | FGF18; Fibroblast growth factor 18; FGF-18; zFGF5 |
UniProt Protein Function: | FGF18: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Belongs to the heparin-binding growth factors family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Cytokine; Secreted Chromosomal Location of Human Ortholog: 5q34 Cellular Component: extracellular region; extracellular space; nucleolus Molecular Function:growth factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding Biological Process: activation of MAPKK activity; anatomical structure morphogenesis; angiogenesis; axon guidance; cell-cell signaling; chondrocyte development; endochondral ossification; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; intramembranous ossification; lung development; MAPKKK cascade; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of MAP kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; Ras protein signal transduction; regulation of endothelial cell proliferation; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway |
NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008] |
UniProt Code: | O76093 |
NCBI GenInfo Identifier: | 6015149 |
NCBI Gene ID: | 8817 |
NCBI Accession: | O76093.1 |
UniProt Secondary Accession: | O76093,Q6UWF1, D3DQL7, |
UniProt Related Accession: | O76093 |
Molecular Weight: | 23,989 Da |
NCBI Full Name: | Fibroblast growth factor 18 |
NCBI Synonym Full Names: | fibroblast growth factor 18 |
NCBI Official Symbol: | FGF18 |
NCBI Official Synonym Symbols: | ZFGF5; FGF-18 |
NCBI Protein Information: | fibroblast growth factor 18 |
UniProt Protein Name: | Fibroblast growth factor 18 |
UniProt Synonym Protein Names: | zFGF5 |
Protein Family: | Fibroblast growth factor |
UniProt Gene Name: | FGF18 |
UniProt Entry Name: | FGF18_HUMAN |