FFAR4 Antibody (PACO06524)
- SKU:
- PACO06524
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | FFAR4 Antibody (PACO06524) |
抗体コード: | PACO06524 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:5000, WB:1:500-1:2000, IF:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from the Internal region of human GPR120. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot analysis of HepG2-UV cells using GPR120 Polyclonal Antibody. | |
Western Blot analysis of HEPG2-UV cells using GPR120 Polyclonal Antibody. |
シノニム: | O3FAR1; GPR120; GPR129; PGR4; Omega-3 fatty acid, receptor 1; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4 |
UniProt Protein Function: | GPR120: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid-binding; Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 10q23.33 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:fatty acid binding; peptide binding; taste receptor activity Biological Process: cellular response to hormone stimulus; hormone secretion; negative regulation of apoptosis; negative regulation of cytokine secretion; negative regulation of inflammatory response Disease: Body Mass Index Quantitative Trait Locus 10 |
NCBI Summary: | This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q5NUL3 |
NCBI GenInfo Identifier: | 82581671 |
NCBI Gene ID: | 338557 |
NCBI Accession: | Q5NUL3.2 |
UniProt Secondary Accession: | Q5NUL3,Q495H1, Q5VY25, Q5VY26, Q7Z605, Q86SM7, |
UniProt Related Accession: | Q5NUL3 |
Molecular Weight: | 40,494 Da |
NCBI Full Name: | Free fatty acid receptor 4 |
NCBI Synonym Full Names: | free fatty acid receptor 4 |
NCBI Official Symbol: | FFAR4 |
NCBI Official Synonym Symbols: | GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1 |
NCBI Protein Information: | free fatty acid receptor 4 |
UniProt Protein Name: | Free fatty acid receptor 4 |
UniProt Synonym Protein Names: | G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; Omega-3 fatty acid receptor 1 |
Protein Family: | Free fatty acid receptor |
UniProt Gene Name: | FFAR4 |
UniProt Entry Name: | FFAR4_HUMAN |
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