FFAR1 Antibody, FITC conjugated (PACO56794)
- SKU:
- PACO56794
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | FFAR1 Antibody, FITC conjugated (PACO56794) |
抗体コード: | PACO56794 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Free fatty acid, receptor 1 protein (143-178AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acid, that plays an important role in glucose homeostasis. Fatty acid, binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. |
シノニム: | Free fatty acid, receptor 1 (G-protein coupled receptor 40), FFAR1, GPR40 |
UniProt Protein Function: | FFAR1: Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. Belongs to the G-protein coupled receptor 1 family. |
UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:bioactive lipid receptor activity; G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; lipid binding Biological Process: energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; glucose homeostasis; insulin secretion; positive regulation of calcium ion transport; positive regulation of GTPase activity; positive regulation of insulin secretion; regulation of insulin secretion |
NCBI Summary: | This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009] |
UniProt Code: | O14842 |
NCBI GenInfo Identifier: | 3122157 |
NCBI Gene ID: | 2864 |
NCBI Accession: | O14842.1 |
UniProt Secondary Accession: | O14842,Q0VAS2, Q4VBL4, |
UniProt Related Accession: | O14842 |
Molecular Weight: | |
NCBI Full Name: | Free fatty acid receptor 1 |
NCBI Synonym Full Names: | free fatty acid receptor 1 |
NCBI Official Symbol: | FFAR1 |
NCBI Official Synonym Symbols: | FFA1R; GPR40; GPCR40 |
NCBI Protein Information: | free fatty acid receptor 1 |
UniProt Protein Name: | Free fatty acid receptor 1 |
UniProt Synonym Protein Names: | G-protein coupled receptor 40 |
Protein Family: | Free fatty acid receptor |
UniProt Gene Name: | FFAR1 |
UniProt Entry Name: | FFAR1_HUMAN |